Added medroxyprogesterone acetate (MPA) (#715)

* Add Medroxyprogesterone acetate (MPA)
* Refine dosage
* Migrate to csv
* Add CAS RN for Medroxyprogesterone Acetate
* Update content/zh-cn/docs/medicine/antiandrogen/medroxyprogesterone/index.md
* Update index.md

Signed-off-by: Jaida Wu <mlgmxyysd@meowcat.org>
Signed-off-by: Jaida Wu <i@neko.ink>
Co-authored-by: septs <github@septs.pw>
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Jaida Wu 2023-01-15 15:25:51 +08:00 committed by GitHub
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---
title: 醋酸甲羟孕酮(安宫黄体酮)
description: 醋酸甲羟孕酮Medroxyprogesterone Acetate是一种类固醇孕激素具有抗促性腺激素作用可以抑制体内雄激素水平。在无法获取到醋酸环丙孕酮Cyproterone Acetate时可作为替代品服用但效果稍差。
---
{{< notice warning "" >}}
请仔细阅读说明书并在医师指导下使用药物。
{{< /notice >}}
醋酸甲羟孕酮Medroxyprogesterone Acetate, MPA是一种类固醇孕激素具有抗促性腺激素作用可以抑制体内雄激素水平。[^1] 在无法获取到 [醋酸环丙孕酮Cyproterone Acetate]]({{< ref cyproterone >}}) 时可作为替代品服用,但效果稍差。[^2]
## 基本信息
### 醋酸甲羟孕酮片
```csv
品牌,厂商,规格,性状,批准文号,包装图片
仙琚<sup>&reg;</sup>,浙江仙琚制药股份有限公司,2mg &times; 100 片/瓶,白色片,[国药准字 H33020715](https://www.nmpa.gov.cn/datasearch/search-info.html?nmpa=aWQ9YjQ4MWM3ZWQ4NGNkM2VhNTcxODBmOTk5YmJiZDRjZjYmaXRlbUlkPWZmODA4MDgxODNjYWQ3NTAwMTg0MDg4MWY4NDgxNzlm),![!](/images/medicine/medroxyprogesterone/xianju.jpg)
创盈<sup>&reg;</sup> 斯利安<sup>&reg;</sup>,北京斯利安药业有限公司,250mg &times; 30 片/瓶,白色片,[国药准字 H11021562](https://www.nmpa.gov.cn/datasearch/search-info.html?nmpa=aWQ9ZTBhNTViM2RlOGZjYmFjMjE3NjkxODM1NjIxMmJlMmYmaXRlbUlkPWZmODA4MDgxODNjYWQ3NTAwMTg0MDg4MWY4NDgxNzlm),![!](/images/medicine/medroxyprogesterone/silian.jpg)
博泰维康<sup>&reg;</sup>,南京臣功制药股份有限公司,2mg &times; 100 片/瓶,双凸、椭圆形白色片,[国药准字 H41025341](https://www.nmpa.gov.cn/datasearch/search-info.html?nmpa=aWQ9OWJkMTlhMzI4ZTZlNTg1NDM5MzBlNmEzNTgwOTEyNWQmaXRlbUlkPWZmODA4MDgxODNjYWQ3NTAwMTg0MDg4MWY4NDgxNzlm),![!](/images/medicine/medroxyprogesterone/botaiweikang.jpg)
法禄达<sup>&reg;</sup> FARLUTAL<sup>&reg;</sup>,Pfizer Italia s.r.l.,500mg &times; 30 片/盒,双凸、椭圆形白色片,[H20140648](https://www.nmpa.gov.cn/datasearch/search-info.html?nmpa=aWQ9NTg4MDMyY2EwNTdiOWNjMTJhNDg2YjAwYjNmMGE4ZmEmaXRlbUlkPWZmODA4MDgxODNjYWQ3NTAwMTg0MDg4NjY1NzExODAw),![!](/images/medicine/medroxyprogesterone/pfizer.jpg)
```
- 商品名:醋酸甲羟孕酮片
- [说明书 (仙琚<sup>&reg;</sup>)](/images/medicine/medroxyprogesterone/xianju-manual-zh.png)
## 说明
- 国内还有其他批准上市的品牌,未完全列出
## 使用方式与用量
- 服用方式:口服
- 建议使用剂量:**10 ~ 20 mg/天**[^3]
- 达到效果的情况下尽量减少用量。
- 停药时须逐步减药。
## 副作用
- **血栓栓塞性疾病**:可能导致血栓栓塞和血栓性疾病(例如,血栓性静脉炎、肺栓塞、脑血管功能不全、冠状动脉闭塞、视网膜血栓形成、肠系膜血栓形成)。[^4] [^5]
- **抑郁**MPA 可能会导致抑郁风险升高。[^5]
- **对肝脏的影响**:可能会导致肝功能障碍(如黄疸)。使用前应当检查**肝功能**并定期检查,如果出现或怀疑有此类影响,请停止服用并重新评估风险。[^4]
- **乳腺癌风险**:与雌二醇合用时可一定程度提高其风险。[^5]
- **对视力的影响**:可能会出现原因不明的突然或逐渐丧失部分或全部视力、眼球突出或复视、视乳头水肿或视网膜病变。[^5]
- 肾上腺抑制MPA 可能会导致肾上腺抑制并可能干扰碳水化合物代谢,但不会导致糖尿病。[^4]
- 男性化症状MPA 仍有微弱雄激素效力和糖皮质激素效力,可能引起痤疮、体毛生长、脱发等雄激素敏感症状。[^4]
- 体重变化[^5]
- 体液潴留[^5]
## 成分信息
- 有效成分醋酸甲羟孕酮Medroxyprogesterone Acetate
- 化学名称6α-甲基-17α-羟基孕甾-4-烯-3,20-二酮醋酸酯
- 分子式C<sub>24</sub>H<sub>34</sub>O<sub>4</sub>
- 分子量386.53
- CAS RN[71-58-9](https://webbook.nist.gov/cgi/cbook.cgi?ID=71-58-9)
[^1]: [Medroxyprogesterone Acetate (Pharmacology)](https://en.wikipedia.org/wiki/Medroxyprogesterone_acetate#Pharmacology)
[^2]: [Hormone treatment of the adult transsexual patient](https://pubmed.ncbi.nlm.nih.gov/16286768/)
[^3]: [Medroxyprogesterone Acetate in Gender-Affirming Therapy for Transwomen: Results From a Retrospective Study](https://doi.org/10.1210/jc.2018-02253)
[^4]: [Medroxyprogesterone Acetate (Side effects)](https://en.wikipedia.org/wiki/Medroxyprogesterone_acetate#Side_effects)
[^5]: [Cautions for medroxyPROGESTERone](https://www.drugs.com/monograph/medroxyprogesterone.html#warnings)

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