diff --git a/content/articles/injectable-e2-meta-analysis.md b/content/articles/injectable-e2-meta-analysis.md index b66eb9c..79859cc 100644 --- a/content/articles/injectable-e2-meta-analysis.md +++ b/content/articles/injectable-e2-meta-analysis.md @@ -4,14 +4,14 @@ linkTitle: 注射雌二醇后的血清浓度曲线分析 description: 本文对常用雌二醇注射剂所引起的血清水平进行荟萃分析，旨在帮助使用者了解药物特性、选择其使用量。 author: Aly published: 2021-07-16 -updated: 2022-02-05 -translated: 2022-05-22 +updated: 2022-11-13 +translated: 2023-02-09 translators: - Bersella AI tags: - 雌激素 - 用药途径与剂量 -trackHash: fdd701930bcb4e0f6f2c2ca8df31b80ae016e9a0 +trackHash: 36c823fafdf5c886401a5744f4a881bb6dca60d8 keywords: [雌激素, 注射, '{戊酸,庚酸,环戊丙酸,苯甲酸}雌二醇', 富士日雌, Depo-Estradiol, 用法, 用量, 用药指导] --- @@ -63,9 +63,9 @@ keywords: [雌激素, 注射, '{戊酸,庚酸,环戊丙酸,苯甲酸}雌二醇', | 十一酸雌二醇(4) | EU | 油溶液 | Delestrec, Progynon Depot 100 | | 聚磷酸雌二醇(4) | PEP | 水溶液 | Estradurin | -(1) 作为注射用复方避孕药，也包含一种孕激素（醋酸炔诺酮、醋酸甲羟孕酮或苯乙酮缩二羟孕酮等） -(2) 俗称“富士日雌”——译者注 -(3) 含微晶颗粒 +(1) 作为注射用复方避孕药，也包含一种孕激素（醋酸炔诺酮、醋酸甲羟孕酮或苯乙酮缩二羟孕酮等）\ +(2) 俗称“富士日雌”——译者注\ +(3) 含微晶颗粒\ (4) 不再上市 @@ -102,7 +102,7 @@ EB 注射剂曾被广泛用于科学研究，尤其是在阐释 HPG 轴的功能 | L76 | 3 | 正常绝经前妇女 | 3mg | [Leyendecker et al. (1976)][L76] | | C78 | 22 | 患有无排卵性不孕症的绝经前妇女 | 1mg | [Canales et al. (1978)][C78] | | S78 | 6 | 正常绝经前妇女 | 2.5mg | [Shaw (1978)][S78] | -| T78 | 19 | 患有高泌乳素血症的绝经前妇女 12 人，其中有 7 人的泌乳素恢复正常
（12 人中有 7 人注射两针） | 1mg | [Travaglini et al. (1978)][T78] | +| T78 | 19 | 患有高泌乳素血症的绝经前妇女 12 人，其中 7 人泌乳素恢复正常
（12 人中有 7 人注射两针） | 1mg | [Travaglini et al. (1978)][T78] | | T79 | 18 | 患有高泌乳素血症的绝经前妇女 9 人
（均注射两针，分别仅注射 EB 和同时注射孕激素） | 1mg | [Travaglini et al. (1979)][T79] | | O80 | 10 | 正服用复方避孕药的绝经前妇女 | 5mg | [Oriowo et al. (1980)][O80] | C81 | 14 | 产后哺乳期妇女 7 人（注射两针） | 3mg | [Canales et al. (1981)][C81] | @@ -128,7 +128,7 @@ EB 注射剂曾被广泛用于科学研究，尤其是在阐释 HPG 轴的功能 ![figure](https://transfemscience.org/assets/images/injectable-e2/eb_v3c.svg) -**图 1**：已发表的、单次肌注 EB 油溶液之后 7 日内的雌二醇浓度—时间曲线，及其拟合曲线（加粗黑/白线）。曲线已依内源性分泌量进行修正、并调整摄入量为 5mg，以与分室药代动力学模型相契合。各曲线随后也用相同的模型进行拟合。源数据在他处亦有提供([Google 文档](https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=1819977282); [Plotly 表格](https://chart-studio.plotly.com/~transfemscience/1/))。 +**图 1**：已发表的、单次肌注 EB 油溶液之后 7 日内的雌二醇浓度—时间曲线，及其拟合曲线（加粗黑/白线）。曲线已依内源性分泌量进行修正、并调整摄入量为 5mg，以与分室药代动力学模型相契合。各曲线随后也用相同的模型进行拟合。源数据在他处亦有提供([Google 文档][WEB_31A]; [Plotly 表格][WEB_31B])。 @@ -525,7 +525,7 @@ PEP 主要用于前列腺癌的治疗，但也见于其它需要雌激素的临 | [TransLine (2019)][T19] | 戊酸雌二醇 | 初始/通常剂量：肌注 5-10 mg/周
最高剂量：肌注 20 mg/周 | | | 环戊丙酸雌二醇 | 初始/通常剂量：肌注 1.25-2.5 mg/周
最高剂量：肌注 5 mg/周 | -(1) 还有些其它《指南》，其推荐剂量与间隔显然直接引用自美国内分泌学会版、或 UCSF 版《指南》，故未在此列出；但可于他处查阅([Aly, 2020][ALYW20_GUIDE])。 +(1) 还有些其它《指南》，其推荐剂量与间隔显然直接引用自美国内分泌学会版、或 UCSF 版《指南》，故未在此列出；但可于他处查阅([Aly, 2020][ALYW20_GUIDE])。\ (2) 芬威健康已于 2021 年更新了其《[指南][C15_NEW]》——译者注 @@ -586,7 +586,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 ## 辅助阅读材料 {#update} -- [有关注射用雌二醇的研究项目，及雌二醇水平 - Google 表格][WEB_31A] +- [有关注射用雌二醇的研究项目，及雌二醇水平 - Google 表格][WEB_9B] - [基于可交互网页的 Violet 三室模型曲线拟合器][WEB_9A] - [注射用雌二醇的溶剂，及其成分与特性 - Google 文档][TABLE_51B] - [性激素酯的亲脂性 (Log P) 汇总表格 - Google 文档][TABLE_52C] @@ -632,7 +632,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 - Enever, R. P., Fotherby, K., Naderi, S., & Lewis, G. A. (1983). Long-acting contraceptive agents: The influence of physicochemical properties of some esters of norethisterone upon the plasma levels of free norethisterone. _Steroids_, _41_(3), 381–396. \[DOI:\] - Eriksson, O., Bäckström, T., Stridsberg, M., Hammarlund-Udenaes, M., & Naessén, T. (2006). Differential response to estrogen challenge test in women with and without premenstrual dysphoria. _Psychoneuroendocrinology_, _31_(4), 415–427. \[DOI:\] - Espino y Sosa, S., Cortés Fuentes, M., Gómez Rico, J. A., & Cortés Bonilla, M. (2019). Non-polymeric Microspheres for the Therapeutic Use of Estrogens: An Innovative Technology. In Khan, W. A. (Ed.). _Estrogen_. London: IntechOpen. \[DOI:\] -- _Estradurin® Polyestradiol Phosphate Labels._ Pharmanovia. \[[URL](https://web.archive.org/web/20180102072958/http://pharmanovia.com/product/estradurin/)\] \[[DOCs/PDFs](https://drive.google.com/drive/folders/1eRISjTySJuMpxZYc8FITe4Z3jyUYMcU8)\] +- _Estradurin® Polyestradiol Phosphate Labels._ Pharmanovia. \[[URL](https://web.archive.org/web/20180102072958/http://pharmanovia.com/product/estradurin/)\] \[[DOCs/PDFs](https://files.transfemscience.org/pdfs/misc/Estradurin%20-%20Pharmanovia.zip)\] - Fisher, D., & Shafer, S. (2007). _Fisher/Shafer NONMEM Workshop Pharmacokinetic and Pharmacodynamic Analysis with NONMEM. Basic Concepts._ \[[PDF](https://web.archive.org/web/20210717084442if_/https://wiki.ucl.ac.uk/download/attachments/23206987/Shafer%20NONMEM.pdf)\] - Florence, A. T. (2010). Looking at Formulations. In Florence, A. T. _An Introduction to Clinical Pharmaceutics_ (pp. 69–100). London/Chicago: Pharmaceutical Press. \[[Google Scholar](https://scholar.google.com/scholar?cluster=10923988500882019865)\] \[[Google Books](https://books.google.com/books?id=5wcyP2OBPhoC&pg=PA69)\] - Fotherby, K., Benagiano, G., Toppozada, H. K., Abdel-Rahman, A., Navaroli, F., Arce, B., Ramos-Cordero, R., Gual, C., Landgren, B. M., & Johannisson, E. (1982). A preliminary pharmacological trial of the monthly injectable contraceptive Cycloprovera. _Contraception_, _25_(3), 261–272. \[DOI:\] @@ -760,6 +760,16 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 - Zhang, Y., Huo, M., Zhou, J., & Xie, S. (2010). PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel. _Computer Methods and Programs in Biomedicine_, _99_(3), 306–314. \[DOI:\] - Zhou, X. F., Shao, Q. X., Han, X. J., Weng, L. J., & Sang, G. W. (1998). Pharmacokinetics of medroxyprogesterone acetate after single and multiple injection of Cyclofem® in Chinese women. _Contraception_, _57_(6), 405–411. \[DOI:\] +-------- + +## 译文修订记录 {#revision} + +```csv +日期,详情 +2022 年 5 月 22 日,初次翻译。 +2023 年 2 月 9 日,第一次修订，更新部分链接。（*未对全文进行检视*） +``` + [E59]: https://doi.org/10.1111/j.2042-7158.1959.tb10412.x [V19]: https://doi.org/10.1007/978-981-13-3642-3_7 @@ -833,7 +843,8 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [IP65]: https://docs.google.com/document/d/18BUGz-BuVOjc3eODsha5yWodifabu-uRuhxEUxUu7Go/view [TABLE_31A]: https://imgur.com/a/62NBGrw -[WEB_31A]: https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=1819977282 +[WEB_31A]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view#gid=1819977282 +[WEB_31B]: https://chart-studio.plotly.com/~transfemscience/1/ [S71]: https://unsworks.unsw.edu.au/fapi/datastream/unsworks:65652/SOURCE01?view=true#page=167 [S72a]: https://doi.org/10.1212/WNL.22.4.355 @@ -866,7 +877,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [FIG_2]: https://transfemscience.org/assets/images/injectable-e2/ev_v3c.svg [TABLE_32A]: https://imgur.com/a/62NBGrw -[WEB_32A]: https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=0 +[WEB_32A]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view#gid=0 [WEB_32B]: https://chart-studio.plotly.com/~transfemscience/17/ [R73]: https://doi.org/10.1210/jcem-37-4-574 @@ -875,7 +886,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [L96]: https://doi.org/10.1046/j.1526-4610.1996.3606367.x [FIG_3]: https://transfemscience.org/assets/images/injectable-e2/ec_oil_v3c.svg -[WEB_33A]: https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=675753324 +[WEB_33A]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view#gid=675753324 [WEB_33B]: https://chart-studio.plotly.com/~transfemscience/5/ [F82]: https://doi.org/10.1016/0010-7824(82)90049-X @@ -889,7 +900,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [FIG_4]: https://transfemscience.org/assets/images/injectable-e2/ec_susp_v3c.svg [TABLE_34A]: https://commons.wikimedia.org/wiki/File:Estradiol_levels_after_a_single_subcutaneous_or_intramuscular_injection_of_5_mg_estradiol_cypionate.png [TABLE_34B]: https://commons.wikimedia.org/wiki/File:Estradiol_cypionate_levels_after_a_single_intramuscular_injection_of_5_mg_microcrystalline_estradiol_cypionate_in_aqueous_suspension_in_women.png -[WEB_34A]: https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=1561713713 +[WEB_34A]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view#gid=1561713713 [WEB_34B]: https://chart-studio.plotly.com/~transfemscience/7/ [R86]: https://doi.org/10.1016/0010-7824(86)90046-6 @@ -900,7 +911,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [M95]: https://doi.org/10.1007/BF02436100 [FIG_5]: https://transfemscience.org/assets/images/injectable-e2/een_v3c.svg -[WEB_35A]: https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=1683725929 +[WEB_35A]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view#gid=1683725929 [WEB_35B]: https://chart-studio.plotly.com/~transfemscience/9/ [GEPP75]: https://www.worldcat.org/oclc/632312599 @@ -913,7 +924,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [TABLE_36A]: https://commons.wikimedia.org/wiki/File:Estradiol_levels_after_injections_of_estradiol,_estradiol_benzoate,_estradiol_valerate,_and_estradiol_undecylate_in_women.png [TABLE_36B]: https://commons.wikimedia.org/wiki/File:Estradiol_levels_after_a_single_intramuscular_injection_of_10_mg_estradiol_valerate_and_100_mg_estradiol_undecylate.png [TABLE_36C]: https://imgur.com/a/ZYgpTsh -[WEB_36A]: https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=467757621 +[WEB_36A]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view#gid=467757621 [WEB_36B]: https://chart-studio.plotly.com/~transfemscience/11/ [J76]: https://doi.org/10.1016/S0083-6729(08)60965-6 @@ -927,7 +938,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [STEGE96]: https://doi.org/10.1002/(SICI)1097-0045(199605)28:5%3C307::AID-PROS6%3E3.0.CO;2-8 [FIG_7]: https://transfemscience.org/assets/images/injectable-e2/pep_v3c.svg -[WEB_37A]: https://docs.google.com/spreadsheets/d/108SmQhbk_gmG22WBvEcGs4tkT43AzwSBfrgPfDjlePk/view#gid=1263215142 +[WEB_37A]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view#gid=1263215142 [WEB_37B]: https://chart-studio.plotly.com/~transfemscience/13/ [FIG_8]: https://transfemscience.org/assets/images/injectable-e2/all_v3c.svg @@ -958,7 +969,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [KSV16]: https://doi.org/10.1016/j.ejps.2015.12.011 [TABLE_51A]: https://commons.wikimedia.org/wiki/File:Estradiol_levels_after_a_single_5_mg_intramuscular_injection_of_estradiol_esters.png -[TABLE_51B]: https://docs.google.com/document/d/1XJRvPikYmJtxcjBV3ssK3C5v-N6gFrQXCIIVz1amK8o/view#bookmark=id.4o16xc1yn2yk +[TABLE_51B]: https://files.transfemscience.org/pdfs/docs/Injectable%20Estradiol%20Vehicles%20and%20Their%20Compositions%20and%20Properties.pdf [WIKI_51A]: https://en.wikipedia.org/wiki/Estrogen_provocation_test @@ -969,7 +980,7 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [TABLE_52A]: https://commons.wikimedia.org/wiki/File:Idealized_curves_of_estradiol_levels_after_injection_of_different_estradiol_esters_in_women.png [TABLE_52B]: https://imgur.com/a/15LxI3o -[TABLE_52C]: https://docs.google.com/document/d/1nidcOcLjt4jIRUMv3rPgyrY_3zUz8Oa0B_noWnGPm4Q/view +[TABLE_52C]: https://files.transfemscience.org/pdfs/docs/Sex%20Hormone%20Ester%20Lipophilicity%20\(Log%20P\)%20Tables.pdf [TABLE_52D]: https://en.wikipedia.org/wiki/Medroxyprogesterone_acetate#Time%E2%80%93concentration_curves [WEB_52A]: http://www.vcclab.org/lab/alogps/ [WEB_52B]: https://docs.chemaxon.com/display/docs/logp-plugin.md @@ -1033,3 +1044,4 @@ Düsterberg & Nishino (1982) 在其对注射用戊酸雌二醇的研究中，仅 [WEB_8A]: https://github.com/tiliaqt/ [WEB_8B]: https://github.com/tiliaqt/transkit/ [WEB_9A]: https://alyw234237.github.io/v3c-fitter/ +[WEB_9B]: https://docs.google.com/spreadsheets/d/11OLP_rsaES-_aINctDlVNTvupThcsI7YRFeSimmAQV8/view