[Dittrich et al. (2005)][D05] 报告称,经口服戊酸雌二醇合并[促性腺激素释放激素(GnRH)激动剂][wiki11]治疗二年后,女性倾向跨性别者有 5% 报告乳房达到 C 罩杯或更大,30% 报告有 B 罩杯,35% 报告有 A 罩杯,其余 30% 未达到 A 罩杯。但他们指出,有 70% 的个体对乳房发育情况不满意,有意接受隆胸手术。
2. 由 Ada Cheung 及其同行于澳大利亚墨尔本进行的,有关口服孕酮用于激素治疗的多项[前瞻性][wiki22] [观察性][wiki23]研究以及一项随机对照试验<sup>([University of Melbourne][UM1]; [University of Melbourne][UM2])</sup>;
3. 由 Ada Cheung 及其同行于澳大利亚墨尔本进行的,有关雌二醇—螺内酯复方和雌二醇—CPA 复方之对比的一项随机对照试验<sup>([ANZCTR][ANZCTR1]; [WHO ICTRP][WHO1]; [Trans Health Research][THR1] \[[传单][WIX1]] \[[海报][THR2]]; [University of Melbourne][UM3])</sup>;
4. 由 Martin den Heijer 及其同行于荷兰[阿姆斯特丹自由大学医学中心][wiki24](VUMC)进行的,有关不同剂量的口服孕酮用于激素治疗的一项大型随机对照试验<sup>([汇总资料和链接][VUMC-PDF]; [资料单荷兰语原文][VUMC-DUTCH]; [资料单英译文][VUMC-ENG])</sup>。
已有 [17α-羟化酶/17,20-裂解酶不足][wiki61]的女孩接受雌激素治疗后出现乳房发育不良的报告;同时,高孕酮水平的早期暴露被猜测是仅次于此状况的原因<sup>([Turan et al., 2009][T09]; [Athanasoulia et al., 2013][ATHA13]; [Deeb et al., 2015][D15]; [Çamtosun et al., 2017][C17]; [Fernández-Cancio et al., 2017][FC17]; [Kardelen et al., 2018][K18])</sup>。然而,这仅仅出于理论,目前尚无证据表明孕酮与乳房发育不良存在明确因果关系。
## 另见 {#additional-content}
- [女性化激素治疗 § 孕激素 - 维基百科][wiki62-p]
## 参考文献 {#references}
- Adams, R. D., Kliman, B., Federman, D. D., Ulfelder, H. S., & Holmes, L. B. (1970). Syndromes of Testicular Feminization. *Clinical Pediatrics*, *9*(3), 165–178. \[DOI:[10.1177/000992287000900312][A70]]
- Alex, A., Bhandary, E., & McGuire, K. P. (2020). Diseases of the Breast during Pregnancy and Lactation. In Alipour, S., & Omranipour, R. (Eds.). *Diseases of the Breast during Pregnancy and Lactation* (*Advances in Experimental Medicine and Biology, Volume 1252*). Cham: Springer International Publishing. \[DOI:[10.1007/978-3-030-41596-9][ABM20]]
- Apter, D. (1980). Serum steroids and pituitary hormones in female puberty: a partly longitudinal study. *Clinical Endocrinology*, *12*(2), 107–120. \[DOI:[10.1111/j.1365-2265.1980.tb02125.x][A80]]
- Apter, D., Räisänen, I., Ylöstalo, P., & Vihko, R. (1987). Follicular growth in relation to serum hormonal patterns in adolescent compared with adult menstrual cycles. *Fertility and Sterility*, *47*(1), 82–88. \[DOI:[10.1016/s0015-0282(16)49940-1][A87]]
- Athanasoulia, A., Auer, M., Riepe, F., & Stalla, G. (2013). Rare Missense P450c17 (CYP17A1) Mutation in Exon 1 as a Cause of 46,XY Disorder of Sexual Development: Implications of Breast Tissue ‘Unresponsiveness’ despite Adequate Estradiol Substitution. *Sexual Development*, *7*(4), 212–215. \[DOI:[10.1159/000348301][ATHA13]]
- Aupperlee, M. D., Leipprandt, J. R., Bennett, J. M., Schwartz, R. C., & Haslam, S. Z. (2013). Amphiregulin mediates progesterone-induced mammary ductal development during puberty. *Breast Cancer Research*, *15*(3), R44. \[DOI:[10.1186/bcr3431][A13]]
- Baker, S. B., Burkey, B. A., Thornton, P., & LaRossa, D. (2001). Juvenile Gigantomastia: Presentation of Four Cases and Review of the Literature. *Annals of Plastic Surgery*, *46*(5), 517–526. \[DOI:[10.1097/00000637-200105000-00011][B01]]
- Bames, H. O. (1948). Reduction of massive breast hypertrophy. *Plastic and Reconstructive Surgery*, *3*(5), 560–569. \[DOI:[10.1097/00006534-194809000-00006][B48]]
- Barbieri, R. L. (2019). Breast. In Strauss, J. F., & Barbieri, R. L. (Eds.). *Yen and Jaffe’s Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, 8th Edition* (pp. 248–255.e3). Philadelphia: Elsevier. \[[Google 阅读][B17-GB]] \[DOI:[10.1016/B978-0-323-47912-7.00010-X][B17]]
- Barrat, J., de Lignières, B., Marpeau, L., Larue, L., Fournier, S., Nahoul, K., Linares, G., Giorgi, H., & Contesso, G. (1990). Effet in vivo de l’administration locale de progestérone sur l’activité mitotique des galactophores humains. Résultat d’une étude pilote. \[The in vivo effect of the local administration of progesterone on the mitotic activity of human ductal breast tissue. Results of a pilot study.] *Journal de Gynecologie, Obstetrique et Biologie de la Reproduction*, *19*(3), 269–274. \[[Google 学术 1][B90-GS1]] \[[Google 学术 2][B90-GS2]] \[[PubMed][B90]]
- Bässler, R. (1970). The Morphology of Hormone Induced Structural Changes in the Female Breast. In Altmann, H.-W., et al. (Eds.). *Current Topics in Pathology: Ergebnisse der Pathology, Volume 53* (pp. 1–89). Heidelberg: Springer Berlin. \[DOI:[10.1007/978-3-662-30514-0\_1][B70]] \[[PDF][B70-PDF]] ——*译者注:未发现原文有引用*
- Bauman, A., Novello, L., & Kreitzer, P. (2016). Endocrine Disorders and Delayed Puberty. In Appelbaum, H. (Ed.). *Abnormal Female Puberty: A Clinical Casebook* (pp. 87–107). Cham: Springer. \[DOI:[10.1007/978-3-319-27225-2\_5][BNK16]]
- Begley, D. J., Firth, J. A., & Hoult, J. R. (1980). The Breast and Lactation. In Begley, D. J., Firth, J. A., & Hoult, J. R. *Human Reproduction and Developmental Biology* (pp. 204–219). London: Macmillan Education UK. \[DOI:[10.1007/978-1-349-16260-4\_14][BFH80]]
- Beyer, C., Cruz, M. L., & Martinez-Manautou, J. (1970). Effect of Chlormadinone Acetate on Mammary Development and Lactation in the Rabbit. *Endocrinology*, *86*(5), 1172–1174. \[DOI:[10.1210/endo-86-5-1172][BCM70]]
- Bland, K. I., Copeland, E. M., & Klimberg, V. S. (2018). Anatomy of the Breast, Axilla, Chest Wall, and Related Metastatic Sites. In Bland, K. I., Copeland, E. M., Klimberg, V. S., Gradishar, W. J., White, J., & Korourian, S. (Eds.). *The Breast: Comprehensive Management of Benign and Malignant Diseases, 5th Edition* (pp. 20–36.e2). Philadelphia: Elsevier. \[DOI:[10.1016/b978-0-323-35955-9.00002-7][BCK18]]
- Bland, K. I., Harrison Howard, J., & Romrell, L. J. (2009). Congenital and Acquired Disturbances of Breast Development and Growth. In Bland, K. I., & Copeland, E. M. (Eds.). *The Breast: Comprehensive Management of Benign and Malignant Diseases, 4th Edition* (pp. 189–207). Philadelphia: Saunders/Elsevier. \[[Google 学术][BHR09-GS]] \[[Google 阅读][BHR09]] \[[OpenLibrary][BHR09-OL]] \[[WorldCat][BHR09-WC]]
- Bondy, C. A., & Turner Syndrome Consensus Study Group. (2007). Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. *The Journal of Clinical Endocrinology & Metabolism*, *92*(1), 10–25. \[DOI:[10.1210/jc.2006-1374][B07]]
- Boogers, L., Infirri, S. S., Bouchareb, A., de Blok, C., Liberton, N., van Trotsenburg, P., Dreijerink, K., den Heijer, M., Wiepjes, C., & Hannema, S. (2022). The effect of timing of puberty suppression on breast development in trans girls; a cross-sectional study. *Hormone Research in Paediatrics*, *95*(Suppl 2) \[*60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022*], 390–391 (abstract no. P1-379). \[[Google 学术][B22-GS]] \[DOI:[10.1159/000525606][B22-DOI]] \[[URL][B22]] \[[PDF 1][B22-PDF1]] \[[PDF 2][B22-PDF2]]
- Boyce, S. W., Hoffman, P. G., & Mathes, S. J. (1984). Recurrent Macromastia after Subcutaneous Mastectomy. *Annals of Plastic Surgery*, *13*(6), 511–518. \[DOI:[10.1097/00000637-198412000-00008][BHM84]]
- Bryant, R., Underwood, A., Robinson, A., Stephenson, T., & Underwood, J. (1998). Determination of breast tissue composition for improved accuracy in estimating radiation doses and risks in mammographic screening. *The Breast*, *7*(2), 95–98. \[DOI:[10.1016/s0960-9776(98)90064-9][B98]]
- Çamtosun, E., Şıklar, Z., Ceylaner, S., Kocaay, P., & Berberoğlu, M. (2017). Delayed Diagnosis of a 17-Hydroxylase/17,20-Lyase Deficient Patient Presenting as a 46,XY Female: A Low Normal Potassium Level Can Be an Alerting Diagnostic Sign. *Journal of Clinical Research in Pediatric Endocrinology*, *9*(2), 163–167. \[DOI:[10.4274/jcrpe.3839][C17]]
- Carlson, L. J., & Shaw, N. D. (2019). Development of Ovulatory Menstrual Cycles in Adolescent Girls. *Journal of Pediatric and Adolescent Gynecology*, *32*(3), 249–253. \[DOI:[10.1016/j.jpag.2019.02.119][CS19]]
- Chang, K., Lee, T. T., Linares-Cruz, G., Fournier, S., & de Ligniéres, B. (1995). Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. *Fertility and Sterility*, *63*(4), 785–791. \[DOI:[10.1016/s0015-0282(16)57482-2][C95]]
- Cheikhelard, A., Morel, Y., Thibaud, E., Lortat-Jacob, S., Jaubert, F., Polak, M., & Nihoul-Fekete, C. (2008). Long-Term Followup and Comparison Between Genotype and Phenotype in 29 Cases of Complete Androgen Insensitivity Syndrome. *Journal of Urology*, *180*(4), 1496–1501. \[DOI:[10.1016/j.juro.2008.06.045][C08]]
- Ciarloni, L., Mallepell, S., & Brisken, C. (2007). Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development. *Proceedings of the National Academy of Sciences*, *104*(13), 5455–5460. \[DOI:[10.1073/pnas.0611647104][CMB07]]
- Cline, J. M., & Wood, C. E. (2006). Hormonal Effects on the Mammary Gland of Postmenopausal Nonhuman Primates. *Breast Disease*, *24*(1), 59–70. \[DOI:[10.3233/bd-2006-24105][CW06]]
- Colvin, C., Devineni, G., & Ashraf, A. P. (2014). Delayed Puberty. In Bandeira, F., Gharib, H., Golbert, A., Griz, L., & Faria, M. (Eds.). *Endocrinology and Diabetes* (pp. 203–217). New York: Springer. \[DOI:[10.1007/978-1-4614-8684-8\_17][CDA14]]
- Crowley, W. F., & Pitteloud, N. (2020). *Approach to the patient with delayed puberty.* UpToDate. \[[Google 学术][CP20-GS]] \[[URL][CP20]]
- de Blok, C. J., Dijkman, B. A., Wiepjes, C. M., Staphorsius, A. S., Timmermans, F. W., Smit, J. M., Dreijerink, K. M., & den Heijer, M. (2020). Sustained Breast Development and Breast Anthropometric Changes in 3 Years of Gender-Affirming Hormone Treatment. *The Journal of Clinical Endocrinology & Metabolism*, *106*(2), e782–e790. \[DOI:[10.1210/clinem/dgaa841][DB20]]
- de Blok, C. J., Klaver, M., Wiepjes, C. M., Nota, N. M., Heijboer, A. C., Fisher, A. D., Schreiner, T., T’Sjoen, G., & den Heijer, M. (2017). Breast Development in Transwomen After 1 Year of Cross-Sex Hormone Therapy: Results of a Prospective Multicenter Study. *The Journal of Clinical Endocrinology & Metabolism*, *103*(2), 532–538. \[DOI:[10.1210/jc.2017-01927][DB18]]
- de Lignières, B. (2002). Effects of progestogens on the postmenopausal breast. *Climacteric*, *5*(3), 229–235. \[DOI:[10.1080/cmt.5.3.229.235][DL02]]
- Dancey, A., Khan, M., Dawson, J., & Peart, F. (2008). Gigantomastia – a classification and review of the literature. *Journal of Plastic, Reconstructive & Aesthetic Surgery*, *61*(5), 493–502. \[DOI:[10.1016/j.bjps.2007.10.041][D08]]
- Davis, M. E., Boynton, M. W., Ferguson, J. H., & Rothman, S. (1945). Studies on Pigmentation of Endocrine Origin. *The Journal of Clinical Endocrinology & Metabolism*, *5*(3), 138–146. \[DOI:[10.1210/jcem-5-3-138][D45]]
- Deeb, A., Al Suwaidi, H., Attia, S., & Al Ameri, A. (2015). 17-hydroxylase/17,20-lyase deficiency due to a R96Q mutation causing hypertension and poor breast development. *Endocrinology, Diabetes & Metabolism Case Reports*, *2015*(1), 15-0069. \[DOI:[10.1530/EDM-15-0069][D15]]
- Dewhurst, C. (1971). The XY female. *American Journal of Obstetrics and Gynecology*, *109*(5), 675–688. \[DOI:[10.1016/0002-9378(71)90753-8][D71]]
- Dewhurst, C., & Spence, J. E. (1977). The XY female. *British Journal of Hospital Medicine*, *17*(5), 498, 501–506. \[[Google 学术][DS77-GS]] \[[PubMed][DS77]] \[[PDF][DS77-PDF]]
- Dittrich, R., Binder, H., Cupisti, S., Hoffmann, I., Beckmann, M., & Mueller, A. (2005). Endocrine Treatment of Male-to-Female Transsexuals Using Gonadotropin-Releasing Hormone Agonist.*Experimental and Clinical Endocrinology & Diabetes*,*113*(10), 586–592. \[DOI:[10.1055/s-2005-865900][D05]]
- Donaldson, M., Kriström, B., Ankarberg-Lindgren, C., Verlinde, S., van Alfen-van der Velden, J., Gawlik, A., van Gelder, M., Sas, T., & (2019). Optimal Pubertal Induction in Girls with Turner Syndrome Using Either Oral or Transdermal Estradiol: A Proposed Modern Strategy. *Hormone Research in Paediatrics*, *91*(3), 153–163. \[DOI:[10.1159/000500050][D19]]
- Drife, J. O. (1986). Breast Development in Puberty. *Annals of the New York Academy of Sciences*, *464*(1) \[*Endocrinology of the Breast: Basic and Clinical Aspects*], 58–65. \[DOI:[10.1111/j.1749-6632.1986.tb15993.x][D86]]
- Döring, G. K. (1963). Über die relative Häufigkeit des anovulatorischen Cyclus im Leben der Frau. *Archiv für Gynäkologie*, *199*(2), 115–123. \[DOI:[10.1007/bf00668062][D63]]
- Federici, S., Goggi, G., Quinton, R., Giovanelli, L., Persani, L., Cangiano, B., & Bonomi, M. (2021). New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature. *Endocrine Reviews*, *43*(5), 824–851. \[DOI:[10.1210/endrev/bnab043][F22]]
- Fernández-Cancio, M., García-García, E., González-Cejudo, C., Martínez-Maestre, M., Mangas-Cruz, M., Guerra-Junior, G., Pandi de Mello, M., Arnhold, I. J., Nishi, M. Y., Bilharinho Mendonça, B., García-Arumí, E., Audí, L., Tizzano, E., & Carrascosa, A. (2017). Discordant Genotypic Sex and Phenotype Variations in Two Spanish Siblings with 17α-Hydroxylase/17,20-Lyase Deficiency Carrying the Most Prevalent Mutated CYP17A1 Alleles of Brazilian Patients. *Sexual Development*, *11*(2), 70–77. \[DOI:[10.1159/000468160][FC17]]
- Finkenzeller, D. A., & Loveless, M. B. (2007). Pediatric Gynecology. In Fortner, K. B., Szymanski, L. M., Fox, H. E., & Wallach, E. E. (Eds.). *The Johns Hopkins Manual of Gynecology and Obstetrics, 3rd Edition* (*Spiral Manual Series*) (pp. 363–379)*.* Philadelphia: Lippincott Williams & Wilkins. \[[Google 学术][F07-GS]] \[[Google 阅读][F07]] \[[OpenLibrary][F07-OL]] \[[WorldCat][F07-WC]] \[[Archive.org][F07-AC]]
- Fisher, A. D., Castellini, G., Ristori, J., Casale, H., Cassioli, E., Sensi, C., Fanni, E., Amato, A. M., Bettini, E., Mosconi, M., Dèttore, D., Ricca, V., & Maggi, M. (2016). Cross-Sex Hormone Treatment and Psychobiological Changes in Transsexual Persons: Two-Year Follow-Up Data. *The Journal of Clinical Endocrinology & Metabolism*, *101*(11), 4260–4269. \[DOI:[10.1210/jc.2016-1276][F16]]
- Foidart, J. M., Colin, C., Denoo, X., Desreux, J., Fournier, S., & de Linières, B. (1996). Influence of percutaneous administration of estradiol and progesterone on the proliferation of human breast epithelial cells. In Calvo, F., Crépin, M., & Magdelenat, H. (Eds.). *Breast Cancer. Advances in Biology and Therapuetics.* John Libbey Eurotext, 329–334. \[[Google 学术][F96-GS]] \[[Google 阅读][F96]]
- Foidart, J., Colin, C., Denoo, X., Desreux, J., Béliard, A., Fournier, S., & de Lignières, B. (1998). Estradiol and Progesterone Regulate the Proliferation of Human Breast Epithelial Cells. *Fertility and Sterility*, *69*(5), 963–969. \[DOI:[10.1016/s0015-0282(98)00042-9][F98]]
- Galani, A., Kitsiou-Tzeli, S., Sofokleous, C., Kanavakis, E., & Kalpini-Mavrou, A. (2008). Androgen insensitivity syndrome: clinical features and molecular defects. *Hormones*, *7*(3), 217–229. \[DOI:[10.14310/horm.2002.1201][G08]]
- Gawlik, A., Hankus, M., Such, K., Drosdzol-Cop, A., Madej, P., Borkowska, M., Zachurzok, A., & Malecka-Tendera, E. (2016). Hypogonadism and Sex Steroid Replacement Therapy in Girls with Turner Syndrome. *Journal of Pediatric and Adolescent Gynecology*, *29*(6), 542–550. \[DOI:[10.1016/j.jpag.2016.03.005][G16]]
- Gertig, D. M., Stillman, I. E., Byrne, C., Spiegelman, D., Schnitt, S. J., Connolly, J. L., Colditz, G. A., & Hunter, D. J. (1999). Association of age and reproductive factors with benign breast tissue composition.*Cancer Epidemiology, Biomarkers & Prevention*,*8*(10), 873–879. \[[Google 学术][G99-GS]] \[[PubMed][G99-PM]] \[[URL][G99]]
- Glenn, J. F. (1976). Testicular feminization syndrome current clinical considerations. *Urology*, *7*(6), 569–577. \[DOI:[10.1016/0090-4295(76)90079-0][G76]]
- Gliosci, A., & Presutti, F. (1993). Virginal gigantomastia: Validity of combined surgical and hormonal treatments. *Aesthetic Plastic Surgery*, *17*(1), 61–65. \[DOI:[10.1007/bf00455051][GP93]]
- Gompel, A., & Plu-Bureau, G. (2018). Progesterone, progestins and the breast in menopause treatment. *Climacteric*, *21*(4), 326–332. \[DOI:[10.1080/13697137.2018.1476483][GP18]]
- Gunn, H. M., Tsai, M., McRae, A., & Steinbeck, K. S. (2018). Menstrual Patterns in the First Gynecological Year: A Systematic Review. *Journal of Pediatric and Adolescent Gynecology*, *31*(6), 557–565.e6. \[DOI:[10.1016/j.jpag.2018.07.009][G18]]
- Hagisawa, S., Shimura, N., & Arisaka, O. (2012). Effect of Excess Estrogen on Breast and External Genitalia Development in Growth Hormone Deficiency. *Journal of Pediatric and Adolescent Gynecology*, *25*(3), e61–e63. \[DOI:[10.1016/j.jpag.2011.11.005][HSA12]]
- Heald, F. P. (Ed.). (1966). *Adolescent Gynecology*. Baltimore: Williams & Wilkins. \[[Google 学术][MA66]] \[[Google 阅读][MA66-GB]] \[[OpenLibrary][MA66-OL]] \[[WorldCat][MA66-WC]] ——*译者注:原文引用为“McArthur, 1966”*
- Heath, R. A., & Wynne, K. (2019). Children and Adolescents. In Heath, R. A., & Wynne, K. *A Guide to Transgender Health: State-of-the-art Information for Gender-Affirming People and Their Supporters* (pp. 87–106). Santa Barbara: Praeger/ABC-CLIO. \[[Google 阅读][HW19A]]
- Heath, R. A., & Wynne, K. (2019). Hormone and Surgical Therapies for Adults. In Heath, R. A., & Wynne, K. *A Guide to Transgender Health: State-of-the-art Information for Gender-Affirming People and Their* Supporters (pp. 107–146). Santa Barbara: Praeger/ABC-CLIO. \[[Google 阅读][HW19B]]
- Hertz, R., Odell, W. D., & Ross, G. T. (1966). Diagnostic Implications of Primary Amenorrhea: Combined Clinical Staff Conference at the National Institutes of Health. *Annals of Internal Medicine*, *65*(4), 800–820. \[DOI:[10.7326/0003-4819-65-4-800][H66]]
- Hillard, P. J. A. (2007). Benign Diseases of the Female Reproductive Tract. In Berek, J. S., & Novak, E. (Eds.). *Berek & Novak’s Gynecology, 14th Edition* (pp. 431–496). Philadelphia: Lippincott Williams and Wilkins, 431–496. \[[Google 学术][H07]] \[[OpenLibrary][H07-OL]] \[[WorldCat][H07-WC]] \[[Archive.org][H07-AC]]
- Hoppe, I. C., Patel, P. P., Singer-Granick, C. J., & Granick, M. S. (2011). Virginal Mammary Hypertrophy: A Meta-Analysis and Treatment Algorithm. *Plastic and Reconstructive Surgery*, *127*(6), 2224–2231. \[DOI:[10.1097/prs.0b013e3182131bd1][H11]]
- Howard, B. A., & Gusterson, B. A. (2000). Human Breast Development. *Journal of Mammary Gland Biology and Neoplasia*, *5*(2), 119–137. \[DOI:[10.1023/a:1026487120779][HG00]]
- Hutson, S. W., Cowen, P. N., & Bird, C. C. (1985). Morphometric studies of age related changes in normal human breast and their significance for evolution of mammary cancer. *Journal of Clinical Pathology*, *38*(3), 281–287. \[DOI:[10.1136/jcp.38.3.281][HCB85]]
- Igo, J., & Visram, H. (2021). Progesterone Therapy Use and Safety in Male to Female Transgender Patients. Canadian Journal of Diabetes, 45(7 Suppl), S39–S39 (abstract no. 109). \[DOI:[10.1016/j.jcjd.2021.09.119][IV21]]
- Ismail, P. M., Amato, P., Soyal, S. M., DeMayo, F. J., Conneely, O. M., O’Malley, B. W., & Lydon, J. P. (2003). Progesterone involvement in breast development and tumorigenesis—as revealed by progesterone receptor “knockout” and “knockin” mouse models. *Steroids*, *68*(10–13), 779–787. \[DOI:[10.1016/s0039-128x(03)00133-8][I03]]
- Iwamoto, S. J., Defreyne, J., Rothman, M. S., Van Schuylenbergh, J., Van de Bruaene, L., Motmans, J., & T’Sjoen, G. (2019). Health considerations for transgender women and remaining unknowns: a narrative review. *Therapeutic Advances in Endocrinology and Metabolism*, *10*, 204201881987116. \[DOI:[10.1177/2042018819871166][I19]]
- Jain, J., Kwan, D., & Forcier, M. (2019). Medroxyprogesterone Acetate in Gender-Affirming Therapy for Transwomen: Results From a Retrospective Study.*The Journal of Clinical Endocrinology & Metabolism*,*104*(11), 5148–5156. \[DOI:[10.1210/jc.2018-02253][JKF19]]
- Kaiser, U., & Ho, K. K. (2015). Pituitary Physiology and Diagnostic Evaluation. In Melmed, S., Polonsky, K. S., Larsen, P. R., Kronenberg, & H. M. (Eds.). *Williams Textbook of Endocrinology, 13th Edition* (pp. 176–231). Philadelphia: Elsevier. \[DOI:[10.1016/B978-0-323-29738-7.00008-3][KH15]] \[[Google 阅读][KH15-GB]]
- Kanhai, R. C., Hage, J. J., Asscheman, H., Mulder, W. J., & Hage, J. J. (1999). Augmentation Mammaplasty in Male-to-Female Transsexuals. *Plastic and Reconstructive Surgery*, *104*(2), 542–549. \[DOI:[10.1097/00006534-199908000-00040][K99]]
- Kanhai, R. C., Hage, J. J., van Diest, P. J., Bloemena, E., & Mulder, J. W. (2000). Short-Term and Long-Term Histologic Effects of Castration and Estrogen Treatment on Breast Tissue of 14 Male-to-Female Transsexuals in Comparison With Two Chemically Castrated Men. *The American Journal of Surgical Pathology*, *24*(1), 74–80. \[DOI:[10.1097/00000478-200001000-00009][K00]]
- Kardelen, A. D., Toksoy, G., Baş, F., Yavaş Abalı, Z., Gençay, G., Poyrazoğlu, Ş., Bundak, R., Altunoğlu, U., Avcı, Ş., Najaflı, A., Uyguner, O., Karaman, B., Başaran, S., & Darendeliler, F. (2018). A Rare Cause of Congenital Adrenal Hyperplasia: Clinical and Genetic Findings and Follow-up Characteristics of Six Patients with 17-Hydroxylase Deficiency Including Two Novel Mutations. *Journal of Clinical Research in Pediatric Endocrinology*, *10*(3), 206–215. \[DOI:[10.4274/jcrpe.0032][K18]]
- Kariagina, A., Xie, J., Leipprandt, J. R., & Haslam, S. Z. (2010). Amphiregulin Mediates Estrogen, Progesterone, and EGFR Signaling in the Normal Rat Mammary Gland and in Hormone-Dependent Rat Mammary Cancers. *Hormones and Cancer*, *1*(5), 229–244. \[DOI:[10.1007/s12672-010-0048-0][K10]]
- Kennedy, B. J. (1953). Effects of intensive sex steroid hormone therapy in advanced breast cancer. *JAMA*, *152*(12), 1135–1141. \[DOI:[10.1001/jama.1953.63690120004013][KN53]]
- Khoo, S. K., & Mackay, E. V. (1972). Testicular Feminization: The Clinical Features, Endocrine Function and Gonadal Pathology in Six Patients. *The Australian and New Zealand Journal of Obstetrics and Gynaecology*, *12*(1), 1–13. \[DOI:[10.1111/j.1479-828x.1972.tb00721.x][KM72]]
- Kutten, F., Malet, C., & Leygue, E. (1994). Antiestrogen action of progestogens in human breast cells. In Berg, G., & Hammar, M. (Eds.). *The Modern Management of the Menopause: A Perspective for the 21st Century* \[*The Proceedings of the VII International Congress on the Menopause, Stockholm, Sweden 1993*] (pp. 419–433). Canforth: Parthenon. \[[Google 学术][K94-GS]] \[[Google 阅读][K94-GB]] \[[OpenLibrary][K94-OL]] \[[WorldCat][K94-WC]] \[[Archive.org][K94-AC]] \[[PDF][K94]] ——*译者注:原文引用为“Kuttenn et al., 1994”*
- LaMarca, H. L., & Rosen, J. M. (2007). Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage. *Breast Cancer Research*, *9*(4), 304. \[DOI:[10.1186/bcr1740][LR07]]
- Lee, P. A. (2001). Physiology of Puberty. In Becker, K. L., Bilezikian, J. P., Bremner, W. J., Hung, W., Kahn, C. R., Loriaux, D. L., Nylén, E. S., Rebar, R. W., Robertson, G. L., Snider, R. H., Wartofsky, L. (Eds.). *Principles and Practice of Endocrinology and Metabolism, 3rd Edition* (pp. 885–893). Philadelphia: Lippincott Williams & Wilkins. \[[Google 学术][L01-GS]] \[[Google 阅读][L01]] \[[Archive.org][L01-AC]] \[[OpenLibrary][L01-OL]] \[[WorldCat][L01-WC]]
- Lee, S. W., Kwak, D. S., Jung, I. S., Kwak, J. H., Park, J. H., Hong, S. M., Lee, C. B., Park, Y. S., Kim, D. S., Choi, W. H., & Ahn, Y. H. (2015). Partial Androgen Insensitivity Syndrome Presenting with Gynecomastia. *Endocrinology and Metabolism*, *30*(2), 226–230. \[DOI:[10.3803/enm.2015.30.2.226][L15]]
- Lemarchand-Béraud, T., Zufferey, M., Reymond, M., & Rey, I. (1982). Maturation of the Hypothalamo-Pituitary-Ovarian Axis in Adolescent Girls. *The Journal of Clinical Endocrinology & Metabolism*, *54*(2), 241–246. \[DOI:[10.1210/jcem-54-2-241][LB82]]
- Lorincz, A. M., & Sukumar, S. (2006). Molecular links between obesity and breast cancer. *Endocrine-Related Cancer*, *13*(2), 279–292. \[DOI:[10.1677/erc.1.00729][LS06]]
- Lucien, J. N., Ortega, M. T., Calvert, M. E., Smith, C., White, X., Rogers, H., Mosley, B., Agrawal, R., Drude, A., McGee, C., George, M., Brown, A., Downey, K., Wild, C., Njunge, A., Kuzmiak, C. M., Zava, D., Zava, T., Pollard, J., Francis, J., Beery, B. L., Harlin, M., Gonzalez, G. R., & Shaw, N. D. (2022). The Launch of A Girl’s First Period Study: Demystifying Reproductive Hormone Profiles in Adolescent Girls. *Journal of Pediatric and Adolescent Gynecology*, *35*(4), 420–425. \[DOI:[10.1016/j.jpag.2021.12.018][L22]]
- Lydon, J. P., DeMayo, F. J., Funk, C. R., Mani, S. K., Hughes, A. R., Montgomery, C. A., Shyamala, G., Conneely, O. M., & O’Malley, B. W. (1995). Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.. *Genes & Development*, *9*(18), 2266–2278. \[DOI:[10.1101/gad.9.18.2266][L95]]
- Lyons, W. R., & McGinty, D. A. (1941). Effects of estrone and progesterone on male rabbit mammary glands. I. Varying doses of progesterone. *Proceedings of the Society for Experimental Biology and Medicine*, *48*(1), 83–86. \[DOI:[10.3181/00379727-48-13227][LMG41]]
- Malet, C., Gompel, A., Yaneva, H., Cren, H., Fidji, N., Mowszowicz, I., Kuttenn, F., & Mauvais-Jarvis, P. (1991). Estradiol and Progesterone Receptors in Cultured Normal Human Breast Epithelial Cells and Fibroblasts: Immunocytochemical Studies. *The Journal of Clinical Endocrinology & Metabolism*, *73*(1), 8–17. \[DOI:[10.1210/jcem-73-1-8][M91]]
- Marshall, W. A., & Tanner, J. M. (1969). Variations in pattern of pubertal changes in girls. *Archives of Disease in Childhood*, *44*(235), 291–303. \[DOI:[10.1136/adc.44.235.291][MT69]]
- Marshall, W. A. (1978). Puberty. In Falkner, F., & Tanner, J. M. (Eds.). *Human Growth: Postnatal Growth* (pp. 141–181). Boston: Springer US. \[DOI:[10.1007/978-1-4684-2622-9\_6][M78]]
- Mauvais-Jarvis, P., Sitruk-Ware, R., & Kuttenn, F. (1981). Benign Breast Disease. In McGuire, W. L. (Ed.). *Breast Cancer 4: Advances in Research and Treatment* (pp. 51–94). Boston: Springer US. \[DOI:[10.1007/978-1-4615-6571-0\_3][MSK81]]
- Mauvais-Jarvis, P., Kuttenn, F., & Gompel, A. (1986). Antiestrogen action of progesterone in breast tissue. *Breast Cancer Research and Treatment*, *8*(3), 179–188. \[DOI:[10.1007/bf01807330][MKG86]]
- Mauvais-Jarvis, P., Kuttenn, F., & Gompel, A. (1987). Antiestrogen Action of Progesterone in Breast Tissue. *Hormone Research*, *28*(2–4), 212–218. \[DOI:[10.1159/000180946][MKG87]]
- Mauvais-Jarvis, P., Kuttenn, F., Gompel, A., & Benotmane, A. (1987). Action anti-estrogène de la progestérone dans le sein. \[Antiestrogen action of progesterone in the breast]. *Pathologie-Biologie*, *35*(7), 1081–1086. \[[Google 学术 1][MJ87-GS1]] \[[Google 学术 2][MJ87-GS2]] \[[PubMed][MJ87]]
- McBryan, J., Howlin, J., Napoletano, S., & Martin, F. (2008). Amphiregulin: Role in Mammary Gland Development and Breast Cancer. *Journal of Mammary Gland Biology and Neoplasia*, *13*(2), 159–169. \[DOI:[10.1007/s10911-008-9075-7][MB08]]
- McDonough, P. G., Spicer, D. V., Ursin, G., & Pike, M. C. (1996). Progesterone Concentrations—Physiologic or Pharmacologic? *Fertility and Sterility*, *65*(5), 1077–1078. \[DOI:[10.1016/s0015-0282(16)58295-8][SUP96]]
- McMillan, M. (1966). Five cases of testicular feminisation including one with a teratoma of the testis. *The Journal of Pathology and Bacteriology*, *91*(2), 417–427. \[DOI:[10.1002/path.1700910216][MM66]]
- McPhaul, M. J. (2002). Androgen receptor mutations and androgen insensitivity. *Molecular and Cellular Endocrinology*, *198*(1–2), 61–67. \[DOI:[10.1016/s0303-7207(02)00369-6][MP02]]
- Meyer, W. J., Finkelstein, J. W., Stuart, C. A., Webb, A., Smith, E. R., Payer, A. F., & Walker, P. A. (1981). Physical and hormonal evaluation of transsexual patients during hormonal therapy.*Archives of Sexual Behavior*,*10*(4), 347–356. \[DOI:[10.1007/bf01565538][M81]]
- Meyer, W. J., Webb, A., Stuart, C. A., Finkelstein, J. W., Lawrence, B., & Walker, P. A. (1986). Physical and hormonal evaluation of transsexual patients: A longitudinal study.*Archives of Sexual Behavior*,*15*(2), 121–138. \[DOI:[10.1007/bf01542220][M86]]
- Meyer, G., Mayer, M., Mondorf, A., Flügel, A. K., Herrmann, E., & Bojunga, J. (2020). Safety and rapid efficacy of guideline-based gender-affirming hormone therapy: an analysis of 388 individuals diagnosed with gender dysphoria. *European Journal of Endocrinology*, *182*(2), 149–156. \[DOI:[10.1530/eje-19-0463][M20]]
- Morris, J. M. (1953). The syndrome of testicular feminization in male pseudohermaphrodites. *American Journal of Obstetrics and Gynecology*, *65*(6), 1192–1211. \[DOI:[10.1016/0002-9378(53)90359-7][N53]]
- Morris, J. M., & Mahesh, V. B. (1963). Further observations on the syndrome, “testicular feminization”.*American Journal of Obstetrics and Gynecology*,*87*(6), 731–748. \[[Google 学术 1][MM63-GS1]] \[[Google 学术 2][MM63-GS2]] \[[PubMed][MM63]] \[[PDF][MM63-PDF]]
- Naseem, H., Lokman, M., & Fitzgerald, C. (2021). Management of congenital hypogonadotropic hypogonadism in females. *Human Fertility*, advance online publcation. \[DOI:[10.1080/14647273.2021.1998929][NLF21]]
- Nolan, B. J., Frydman, A. S., Leemaqz, S. Y., Carroll, M., Grossmann, M., Zajac, J. D., & Cheung, A. S. (2022). Effects Of Low-dose Oral Micronised Progesterone On Sleep, Psychological Distress And Breast Development In Transgender Individuals Undergoing Feminising Hormone Therapy: A Prospective Controlled Study.*Journal of the Endocrine Society*,*6*(Suppl 1), A653–A654 (abstract no. LBODP089). \[DOI:[10.1210/jendso/bvac150.1351][N22A]]
- Nolan, B. J., Frydman, A. S., Leemaqz, S. Y., Carroll, M., Grossmann, M., Zajac, J. D., & Cheung, A. S. (2022). Effects of low-dose oral micronised progesterone on sleep, psychological distress, and breast development in transgender individuals undergoing feminising hormone therapy: a prospective controlled study. *Endocrine Connections*, *11*(5), e220170. \[DOI:[10.1530/EC-22-0170][N22B]]
- Oakes, M. B., Eyvazzadeh, A. D., Quint, E., & Smith, Y. R. (2008). Complete Androgen Insensitivity Syndrome—A Review. *Journal of Pediatric and Adolescent Gynecology*, *21*(6), 305–310. \[DOI:[10.1016/j.jpag.2007.09.006][O08]]
- Pandya, S., & Moore, R. G. (2011). Breast Development and Anatomy.*Clinical Obstetrics & Gynecology*,*54*(1), 91–95. \[DOI:[10.1097/grf.0b013e318207ffe9][PM11]]
- Pasqualini, J. R. (2007). Progestins and breast cancer. *Gynecological Endocrinology*, *23*(Suppl 1), 32–41. \[DOI:[10.1080/09513590701585003][P07]]
- Pasqualini, J. R. (2009). Breast cancer and steroid metabolizing enzymes: The role of progestogens. *Maturitas*, *65*(Suppl 1), S17–S21. \[DOI:[10.1016/j.maturitas.2009.11.006][P09]]
- Patterson, M. N., McPhaul, M. J., & Hughes, I. A. (1994). Androgen insensitivity syndrome. *Baillière’s Clinical Endocrinology and Metabolism*, *8*(2), 379–404. \[DOI:[10.1016/s0950-351x(05)80258-7][PMH94]]
- Perez-Palacios, G., & Jaffe, R. B. (1972). The Syndrome of Testicular Feminization. *Pediatric Clinics of North America*, *19*(3), 653–667. \[DOI:[10.1016/s0031-3955(16)32744-4][PPJ72]]
- Plu-Bureau, G., Touraine, P., & Mauvais-Jarvis, P. (1999). Interactions Between Estradiol and Progesterone in Normal Breast: Implications for Mammary Carcinogenesis. In Manni, A. (Ed.). *Endocrinology of Breast Cancer* (*Contemporary Endocrinology, Volume 11*) (pp. 21–37). Totowa, New Jersey: Humana Press. \[DOI:[10.1007/978-1-59259-699-7\_2][PTM99]] \[[OpenLibrary][PTM99-OL]] \[[Archive.org][PTM99-AC]]
- Polani, P. E. (1970). Hormonal and clinical aspects of hermaphroditism and the testicular feminizing syndrome in man. *Philosophical Transactions of the Royal Society of London. B, Biological Sciences*, *259*(828), 187–206. \[DOI:[10.1098/rstb.1970.0058][P70]]
- Prior, J. C., Vigna, Y. M., Watson, D., Diewold, P., & Robinow, O. (1986). Spironolactone in the presurgical therapy of male to female transsexuals: Philosophy and experience of the Vancouver Gender Dysphoria Clinic. *Journal of Sex Information & Education Council of Canada*, *1*(1), 1–7. \[[Google 学术][P86-GS]] \[[PDF][P86]]
- Prior, J. C., Vigna, Y. M., & Watson, D. (1989). Spironolactone with physiological female steroids for presurgical therapy of male-to-female transsexualism. *Archives of Sexual Behavior*, *18*(1), 49–57. \[DOI:[10.1007/bf01579291][PVW89]]
- Prior J. C. (2011). Progesterone for Symptomatic Perimenopause Treatment - Progesterone politics, physiology and potential for perimenopause. *Facts, Views & Vision in ObGyn*, *3*(2), 109–120. \[[PubMed][P11-PM]] \[[PubMed Central][P11]] \[[PDF][P11-PDF]]
- Prior, J. C. (2019). Progesterone is Important for Transwomen’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen. *The Journal of Clinical Endocrinology & Metabolism, 104*(4), 1181–1186, \[DOI:[10.1210/jc.2018-01777][P19A]]
- Prior, J. C. (2019). *Response to Letter to the Editor:* “Progesterone is Important for Transwomen’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen”, *The Journal of Clinical Endocrinology & Metabolism*, *104*(8), 3129–3130. \[DOI:[10.1210/jc.2019-00524][P19B]]
- Prior, J. C. (2020). Women’s Reproductive System as Balanced Estradiol and Progesterone Actions—A revolutionary, paradigm-shifting concept in women’s health. *Drug Discovery Today: Disease Models*, *32*(Part B), 31–40. \[DOI:[10.1016/j.ddmod.2020.11.005][P20]]
- Ramsay, D. T., Kent, J. C., Hartmann, R. A., & Hartmann, P. E. (2005). Anatomy of the lactating human breast redefined with ultrasound imaging. *Journal of Anatomy*, *206*(6), 525–534. \[DOI:[10.1111/j.1469-7580.2005.00417.x][R05]]
- Rosenfield, R. L., Cooke, D. W., & Radovick, S. (2021). Puberty in the Female and Its Disorders. In Sperling, M. A., Majzoub, J. A., Menon, R. K., & Stratakis, C. A. (Eds.). *Sperling Pediatric Endocrinology, 5th Edition* (pp. 528–626). Philadelphia: Elsevier. \[DOI:[10.1016/B978-0-323-62520-3.00016-6][RCR21]]
- Quigley, C. A., Bellis, A. D., Marschke, K. B., El-Awady, M. K., Wilson, E. M., & French, F. S. (1995). Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives. *Endocrine Reviews*, *16*(3), 271–321. \[DOI:[10.1210/edrv-16-3-271][Q95]]
- Quigley, C. A. (1998). The androgen receptor: Physiology and pathophysiology. In Nieschlag, E., & Behre, H. M. (Eds.). *Testosterone: Action · Deficiency · Substitution, 2nd Edition* (pp. 33–106). Berlin/Heidelberg: Springer. \[DOI:[10.1007/978-3-642-72185-4\_2][Q88]]
- Ramos, L., Chávez, B., Mares, L., Valdés, E., & Vilchis, F. (2018). Mutational analysis of the androgen receptor (NR3C4) gene in patients with 46,XY DSD. *Gene*, *641*, 86–93. \[DOI:[10.1016/j.gene.2017.10.038][R18]]
- Randolph, J. F. (2018). Gender-Affirming Hormone Therapy for Transgender Females. *Clinical Obstetrics & Gynecology*, *61*(4), 705–721. \[DOI:[10.1097/grf.0000000000000396][RAND18]]
- Reisman, T., Goldstein, Z., & Safer, J. D. (2019). A Review of Breast Development in Cisgender Women and Implications for Transgender Women. *Endocrine Practice*, *25*(12), 1338–1345. \[DOI:[10.4158/ep-2019-0183][RGS19]]
- Rosenfield, R. L. (2013). Adolescent Anovulation: Maturational Mechanisms and Implications. *The Journal of Clinical Endocrinology & Metabolism*, *98*(9), 3572–3583. \[DOI:[10.1210/jc.2013-1770][R13]]
- Rothman, M. S., & Iwamoto, S. J. (2022). Feminizing Gender-Affirming Hormone Therapy: Special Considerations for Older Adults. In Davis, T. F. (Ed.). *A Case-Based Guide to Clinical Endocrinology* (pp. 513–523). Cham: Springer International Publishing. \[DOI:[10.1007/978-3-030-84367-0\_58][RI22]]
- Rutgers, J. L., & Scully, R. E. (1991). The Androgen Insensitivity Syndrome (Testicular Feminization). *International Journal of Gynecological Pathology*, *10*(2), 126–144. \[DOI:[10.1097/00004347-199104000-00002][RS91]]
- Ryan, R. F., & Pernoll, M. L. (1985). Virginal Hypertrophy. *Plastic and Reconstructive Surgery*, *75*(5), 737–742. \[DOI:[10.1097/00006534-198505000-00024][RP85]]
- Saito, R., Yamamoto, Y., Goto, M., Araki, S., Kubo, K., Kawagoe, R., Kawada, Y., Kusuhara, K., Igarashi, M., & Fukami, M. (2014). Tamoxifen Treatment for Pubertal Gynecomastia in Two Siblings with Partial Androgen Insensitivity Syndrome. *Hormone Research in Paediatrics*, *81*(3), 211–216. \[DOI:[10.1159/000356923][S14]]
- Sandhu, R., Chollet-Hinton, L., Kirk, E. L., Midkiff, B., & Troester, M. A. (2016). Digital histologic analysis reveals morphometric patterns of age-related involution in breast epithelium and stroma. *Human Pathology*, *48*, 60–68. \[DOI:[10.1016/j.humpath.2015.09.031][S16]]
- Schindler, A. E. (2010). Dydrogesterone and other progestins in benign breast disease: an overview. *Archives of Gynecology and Obstetrics*, *283*(2), 369–371. \[DOI:[10.1007/s00404-010-1456-7][S11]]
- Shapiro, L. R. (1982). Disorders of Female Sex Differentiation. In Blaustein, A. (Ed.). *Pathology of the Female Genital Tract, 2nd Edition* (pp. 479–510). New York: Springer New York. \[DOI:[10.1007/978-1-4757-1767-9\_20][S82]]
- Shi, H. Y., Lydon, J. P., & Zhang, M. (2004). Hormonal Defect in Maspin Heterozygous Mice Reveals a Role of Progesterone in Pubertal Ductal Development. *Molecular Endocrinology*, *18*(9), 2196–2207. \[DOI:[10.1210/me.2004-0052][SLZ04]]
- Simmer, H. H., Pion, R. J., & Dignam, W. J. (1965). *Testicular Feminization: Endocrine Function of Feminizing Testes, Comparison with Normal Testes*. Springfield, Illinois: Thomas. \[[Google 学术][SPD65-GS]] \[[Google 阅读][SPD65]] \[[OpenLibrary][SPD65-OL]] \[[WorldCat][SPD65-WC]]
- Sizonenko, P. C. (1978). Endocrinology in Preadolescents and Adolescents.*American Journal of Diseases of Children*,*132*(7), 704–712. \[DOI:[10.1001/archpedi.1978.02120320064015][S78]]
- Sosa, M., Jódar, E., Arbelo, E., Domínguez, C., Saavedra, P., Torres, A., Salido, E., de Tejada, M. J., & Hernández, D. (2003). Bone Mass, Bone Turnover, Vitamin D, and Estrogen Receptor Gene Polymorphisms in Male to Female Transsexuals. *Journal of Clinical Densitometry*, *6*(3), 297–304. \[DOI:[10.1385/jcd:6:3:297][S03]]
- Sosa, M., Jódar, E., Arbelo, E., Domı́nguez, C., Saavedra, P., Torres, A., Salido, E., Limiñana, J., Gómez de Tejada, M. J., & Hernández, D. (2004). Serum lipids and estrogen receptor gene polymorphisms in male-to-female transsexuals: effects of estrogen treatment. *European Journal of Internal Medicine*, *15*(4), 231–237. \[DOI:[10.1016/j.ejim.2004.04.009][S04]]
- Sperling, R. L., & Gold, J. J. (1973). Use of an anti-estrogen after a reduction mammaplasty to prevent recurrence of virginal hypertrophy of breasts. *Plastic and Reconstructive Surgery*, *52*(4), 439–442. \[DOI:[10.1097/00006534-197352040-00030][SG73]]
- Sridhar, G. R., & Sinha, M. J. (1995). Macromastia in adolescent girls. *Indian Pediatrics*, *32*(4), 496–499. \[[Google 学术][SS95-GS]] \[[PubMed][SS95-PM]] \[[PDF][SS95]]
- Sun, B. Z., Kangarloo, T., Adams, J. M., Sluss, P. M., Welt, C. K., Chandler, D. W., Zava, D. T., McGrath, J. A., Umbach, D. M., Hall, J. E., & Shaw, N. D. (2018). Healthy Post-Menarchal Adolescent Girls Demonstrate Multi-Level Reproductive Axis Immaturity. *The Journal of Clinical Endocrinology & Metabolism*, *104*(2), 613–623. \[DOI:[10.1210/jc.2018-00595][S19]]
- Sun, S. X., Bostanci, Z., Kass, R. B., Mancino, A. T., Rosenbloom, A. L., Klimberg, V. S., & Bland, K. I. (2018). Breast Physiology: Normal and Abnormal Development and Function. In Bland, K. I., Copeland, E. M., Klimberg, V. S., Gradishar, W. J., White, J., & Korourian, S. (Eds.). *The Breast: Comprehensive Management of Benign and Malignant Diseases, 5th Edition* (pp. 37–56.e6). Philadelphia: Elsevier. \[DOI:[10.1016/b978-0-323-35955-9.00003-9][S18]]
- Tack, L. J., Heyse, R., Craen, M., Dhondt, K., Bossche, H. V., Laridaen, J., & Cools, M. (2017). Consecutive Cyproterone Acetate and Estradiol Treatment in Late-Pubertal Transgender Female Adolescents. *The Journal of Sexual Medicine*, *14*(5), 747–757. \[DOI:[10.1016/j.jsxm.2017.03.251][T17]]
- Talbert, L. M., Hammond, M. G., Groff, T., & Udry, J. R. (1985). Relationship of age and pubertal development to ovulation in adolescent girls. *Obstetrics & Gynecology*, *66*(4), 542–544. \[[Google 学术][T85-GS]] \[[URL][T85]]
- Tiefenbacher, K., & Daxenbichler, G. (2008). The Role of Androgens in Normal and Malignant Breast Tissue. *Breast Care*, *3*(5), 325–331. \[DOI:[10.1159/000158055][TD08]]
- Trabert, B., Sherman, M. E., Kannan, N., & Stanczyk, F. Z. (2019). Progesterone and Breast Cancer. *Endocrine Reviews*, *41*(2), 320–344. \[DOI:[10.1210/endrev/bnz001][T20]]
- Turan, S., Bereket, A., Guran, T., Akcay, T., Papari-Zareei, M., & Auchus, R. J. (2009). Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair. *European Journal of Endocrinology*, *160*(2), 325–330. \[DOI:[10.1530/eje-08-0632][T09]]
- Valentine, G. H. (1969). *The Chromosome Disorders: An Introduction for Clinicians, 2nd Edition.* London: W. Heinemann Medical Books. \[[Google 学术][V69-GS]] \[[Google 阅读][V69]] \[[OpenLibrary][V69-OL]] \[[WorldCat][V69-WC]] \[[Archive.org][V69-AC]]
- Venturoli, S., Porcu, E., Fabbri, R., Magrini, O., Paradisi, R., Pallotti, G., Gammi, L., & Flamigni, C. (1987). Postmenarchal evolution of endocrine pattern and ovarian aspects in adolescents with menstrual irregularities. *Fertility and Sterility*, *48*(1), 78–85. \[DOI:[10.1016/s0015-0282(16)59294-2][V87]]
- Venturoli, S., Fabbri, R., Porcu, E., Paradisi, R., Orsini, L. F., Brondelli, L., Ruggeri, S., & Flamigni, C. (1989). Endocrine and ovarian parameters at various frequencies of ovulation in adolescents. *Archives of Gynecology and Obstetrics*, *246*(2), 107–114. \[DOI:[10.1007/bf00934127][V89]]
- Weisberg, M. G., Malkasian, G. D., & Pratt, J. H. (1970). Testicular feminization syndrome. *American Journal of Obstetrics and Gynecology*, *107*(8), 1181–1187. \[DOI:[10.1016/s0002-9378(15)30367-7][WMP70]]
- Wierckx, K., Gooren, L., & T’Sjoen, G. (2014). Clinical Review: Breast Development in Trans Women Receiving Cross-Sex Hormones. *The Journal of Sexual Medicine*, *11*(5), 1240–1247. \[DOI:[10.1111/jsm.12487][WGT14]]
- Wierckx, K., Van Caenegem, E., Schreiner, T., Haraldsen, I., Fisher, A., Toye, K., Kaufman, J. M., & T’Sjoen, G. (2014). Cross‐Sex Hormone Therapy in Trans Persons Is Safe and Effective at Short‐Time Follow‐Up: Results from the European Network for the Investigation of Gender Incongruence. *The Journal of Sexual Medicine*, *11*(8), 1999–2011. \[DOI:[10.1111/jsm.12571][W14]]
- Wilson, C. L., Sims, A. H., Howell, A., Miller, C. J., & Clarke, R. B. (2006). Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue. *Endocrine-Related Cancer*, *13*(2), 617–628. \[DOI:[10.1677/erc.1.01165][W06]]
- Winkler, U. H., Schindler, A. E., Brinkmann, U. S., Ebert, C., & Oberhoff, C. (2001). Cyclic progestin therapy for the management of mastopathy and mastodynia. *Gynecological Endocrinology*, *15*(Suppl 6), 37–43. \[DOI:[10.1080/gye.15.s6.37.43][W01]]
- Wisniewski, A. B., Migeon, C. J., Meyer-Bahlburg, H. F., Gearhart, J. P., Berkovitz, G. D., Brown, T. R., & Money, J. (2000). Complete Androgen Insensitivity Syndrome: Long-Term Medical, Surgical, and Psychosexual Outcome. *The Journal of Clinical Endocrinology & Metabolism*, *85*(8), 2664–2669. \[DOI:[10.1210/jcem.85.8.6742][W00]]
- Wren, B. G., & Eden, J. A. (1996). Do Progestogens Reduce The Risk of Breast Cancer? A Review of the Evidence. *Menopause*, *3*(1), 4–12. \[DOI:[10.1097/00042192-199603010-00003][WE96]]
- Xu, P., Ye, W., Zhong, S., Li, H., Feng, E., Lin, S. H., Kuo, C. T., Liu, J. Y., & Lin, Y. C. (2010). Leptin and zeranol up-regulate cyclin D1 expression in primary cultured normal human breast pre-adipocytes.*Molecular Medicine Reports*,*3*(6), 983–990. \[DOI:[10.3892/mmr.2010.370][X10]]
- Zacharin, M. (2000). Use of androgens and oestrogens in adolescents - A review of hormone replacement treatment. *Journal of Pediatric Endocrinology and Metabolism*, *13*(1), 3–12. \[DOI:[10.1515/JPEM.2000.13.1.3][Z00]]
- Bessone, F., Lucena, M., Roma, M. G., Stephens, C., Medina-Cáliz, I., Frider, B., Tsariktsian, G., Hernández, N., Bruguera, M., Gualano, G., Fassio, E., Montero, J., Reggiardo, M. V., Ferretti, S., Colombato, L., Tanno, F., Ferrer, J., Zeno, L., Tanno, H., & Andrade, R. J. (2015). Cyproterone acetate induces a wide spectrum of acute liver damage including corticosteroid-responsive hepatitis: report of 22 cases. *Liver International*, *36*(2), 302–310. \[DOI:[10.1111/liv.12899][B16]]
- Bowen, R., Benavides, R., Colón-Franco, J. M., Katzman, B. M., Muthukumar, A., Sadrzadeh, H., Straseski, J., Klause, U., & Tran, N. (2019). Best practices in mitigating the risk of biotin interference with laboratory testing. *Clinical Biochemistry*, *74*, 1–11. \[DOI:[10.1016/j.clinbiochem.2019.08.012][B19]]
- Brown, J., Farquhar, C., Lee, O., Toomath, R., & Jepson, R. G. (2009). Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. *Cochrane Database of Systematic Reviews*, *2009*(2), CD000194. \[DOI:[10.1002/14651858.cd000194.pub2][B09]]
- Burinkul, S., Panyakhamlerd, K., Suwan, A., Tuntiviriyapun, P., & Wainipitapong, S. (2021). Anti-Androgenic Effects Comparison Between Cyproterone Acetate and Spironolactone in Transgender Women: A Randomized Controlled Trial. *The Journal of Sexual Medicine*, *18*(7), 1299–1307. \[DOI:[10.1016/j.jsxm.2021.05.003][B21]]
- Burinkul, S., Panyakhamlerd, K., Suwan, A., Tuntiviriyapun, P., & Wainipitapong, S. (2021). Anti-Androgenic Effects Comparison Between Cyproterone Acetate and Spironolactone in Transgender Women: A Randomized Controlled Trial. *The Journal of Sexual Medicine*, *18*(7), 1299–1307. \[DOI:[10.1016/j.jsxm.2021.05.003][B21]] \[[PDF][B21-PDF]]
- Callen-Lorde Community Health Center. (2018). *Protocols for the Provision of Hormone Therapy*. New York City: Callen-Lorde Community Health Center. \[[URL][CL18-URL]] \[[PDF][CL18]]
- Cappelletti, M., & Wallen, K. (2016). Increasing women’s sexual desire: The comparative effectiveness of estrogens and androgens. *Hormones and Behavior*, *78*, 178–193. \[DOI:[10.1016/j.yhbeh.2015.11.003][CW16]]
- Carmina, E., Stanczyk, F. Z., & Lobo, R. A. (2019). Evaluation of Hormonal Status. In Strauss, J. F., & Barbieri, R. L. (Eds.). *Yen and Jaffe’s Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, 8th Edition*(pp. 887–915.e4). Philadelphia: Elsevier. \[DOI:[10.1016/b978-0-323-47912-7.00034-2][CSL19]]